A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice
June 20, 2024Our paper entitled “A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice” has been published…
Unbounded scaling of dimensionality with neuron number
April 4, 2024Our paper entitled “Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number” has…
Mesoscale volumetric light-field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz
February 24, 2023Our paper entitled “Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz” has been published…
High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using Light Beads Microscopy
August 30, 2021Our paper entitled “High-Speed, Cortex-Wide Volumetric Recording of Neuroactivity at Cellular Resolution using Light Beads Microscopy” has been published in…Neuronal basis of decision making at the single trial level
January 16, 2020Our paper entitled “Cerebellar neurodynamics predict decision timing and outcome on single-trial level” has been published in Cell. Decision making…Volumetric Ca2+ imaging in the mouse brain using Hybrid Multiplexed Sculpted Light Microscopy
April 10, 2019Our paper entitled “Volumetric Ca2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy” has been published…High-speed volumetric imaging of neuronal activity in freely moving rodents
May 7, 2018Our paper entitled “High-speed volumetric imaging of neuronal activity in freely moving rodents” has been published in Nature Methods. We…
Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution
March 29, 2018Our paper entitled "Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution" has been published in Optica. A major…High-speed computational imaging, deep in scattering brain tissue using Seeded Iterative Demixing (SID) Microscopy
June 26, 2017Our paper entitled “Video rate volumetric Ca2+ imaging across cortical layers using Seeded Iterative Demixing (SID) microscopy” has been published…
Fast volumetric calcium imaging across multiple cortical layers using sculpted light
October 31, 2016Our paper entitled “Fast volumetric calcium imaging across multiple cortical layers using sculpted light” has been published in Nature Methods.…Molecular mechanism underlying parallel microtubule bundle formation
October 11, 2016Our paper entitled “A force-induced directional switch of a molecular motor enables parallel microtubule bundle formation” has been published in…Direct detection of a single photon by humans
July 19, 2016Our paper entitled “Direct detection of a single photon by humans” has been published in Nature Communications. As early as…Hybrid light-sculpting-scanning for versatile high-speed calcium imaging
January 15, 2015We have developed strategies for optimizing of the present tradeoffs in light-sculpting microscopy by evaluating various scanning modalities theoretically and…
Simultaneous whole-brain functional imaging of neuronal activity using Light-Field Microscopy
May 18, 2014Our paper entitled “Simultaneous Whole-Brain Functional Imaging of Neuronal Activity using Light-Field Microscopy” has been published in Nature Methods. High-speed,…High-speed brain-wide 3D calcium imaging of neuronal activity with sculpted light
September 9, 2013Wide-field temporal focusing (WF-TEFO) is a two-photon imaging technique which is based on light-sculpting. It effectively decouples the parameters governing…IR-spectroscopy of KcsA binding states
August 26, 2013Most of our today’s understanding on the function of channels is based on static crystallography data and electrophysiology. However, it…Ultrafast widefield optical sectioning microscopy
March 24, 2013The need for optical sectioning in bio-imaging has amongst others led to the development of the two-photon scanning microscopy. However,…Optical force spectroscopy
February 22, 2013Optical trapping is a single molecule technique that allows to study mechanical properties of single polymer molecules, proteins, or individual…
Multilayer three-dimensional super-resolution microscopy
October 24, 2011Photoactivated Localization Microscopy (PALM) is one of the recently emerging techniques for optical imaging of protein distributions in biological samples…Single-neuron-specific optogenetic control
October 24, 2011It is widely accepted that that the patterns of action potentials in neuronal circuits underlie cognitive functions such as perception,…
