New publication in Optica

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Our article entitled “Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution” has been published in Optica.

We introduce a new high-speed 3D imaging modality, speckle light-field microscopy (speckle LFM), which utilizes speckle-based structured illumination to enhance the spatial resolution of light-field microscopy. Using speckle LFM, we demonstrate brain-wide recording of neuronal activity in larval zebrafish at 10 Hz volume rate and at 1.4 times higher resolution compared to conventional light-field microscopy and with suppressed background fluorescence. In addition to improving resolution of spatial structure, we show that the increased resolution reduces spurious signal crosstalk between neighboring neurons.

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