“MiniLFM” published in Nature Methods
Our paper entitled “High-speed volumetric imaging of neuronal activity in freely moving rodents” has been published in Nature Methods. We present a head-mounted (more…)
New publication in Annual Review of Neuroscience
Our review article entitled "A Guide to Emerging Technologies for Large-Scale and Whole-Brain Optical Imaging of Neuronal Activity" has been published (more…)
New publication in Optica
Our article entitled "Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution" has been published in Optica. We introduce a new high-speed (more…)
Solar eclipse in NY
We were watching the solar eclipse in the United States together with the lab. Here are some pictures of us using a telescope and one of the most important tools in an optics (more…)
New publication in Nature Methods
Our paper entitled “Video rate volumetric Ca2+ imaging across cortical layers using Seeded Iterative Demixing (SID) microscopy” has been published in Nature Methods. (more…)
New publication in Nature Methods
Our paper entitled “Fast volumetric calcium imaging across multiple cortical layers using sculpted light” has been published in Nature Methods. In this work, we present a (more…)
New publication in Cell
Our paper entitled "A force-induced directional switch of a molecular motor enables parallel microtubule bundle formation" by Maxim I. Molodtsov et al. has been published in Cell. Microtubule-organizing centers (MTOCs) nucleate microtubules that can grow autonomously in any direction. To generate bundles of parallel microtubules originating from a single MTOC, the growth of multiple microtubules needs to coordinated, but the underlying mechanism is unknown. Here, we show that a conserved two-component system consisting of the plus-endtracker EB1 and the minus-end-directed molecular motor Kinesin-14 is sufficient to promote parallel microtubule growth. The underlying mechanism relies on the ability of Kinesin-14 to guide growing plus ends along existing microtubules. The generality of this finding is supported by yeast, Drosophila, and human EB1/Kinesin-14 pairs. We demonstrate that plus-end guiding involves a directional switch…
New publication in Nature Communications
Our paper entitled “Direct Detection of a Single Photon by Humans” by Tinsley J. N. et. al., has been published in Nature Communications. In this study we have shown that humans are capable of detecting a single photon onto their eyes with a probability above chance. This was done by developing a quantum light source based on spontaneous parametric down-conversion (SPDC) which can generate single-photon states of light and combining it with a state-of-the-art psychophysics procedure. Thereby we could show that the human visual system including the post-processing performed by the retina and the brain can detect a single photon incident onto the eye. Read the publication or a short summary. Please have also a look at the Nature News article by Davide Castelvecchi as well as the articles on…
Congratulations to Qian Lin
We congratulate her on the PhD title awarded by the university of Singapore. Previously, she worked on neurobehavioral manifestations of decision making. Recently, Qian Lin joined our group to strengthen our research focus on whole brain imaging to unravel the collective function of brain structures in simple behavioral paradigms.
We welcome visiting scientists
We welcome Jeroen Delcour (Netherlands) and Ren Zicheng (China) as visiting scientists in our group. They will try to understand specific brain functions by applying our previously developed whole-brain imaging techniques (see our Publications) to animal models.