Preprint: Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level

Preprint: Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level

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We have uploaded a new manuscript entitled "Cerebellar neurodynamics during motor planning predict decision timing and outcome on single-trial level" to the bioRxiv preprint server:The neuronal basis of goal-directed behavior requires interaction of multiple separated brain regions. How subcortical regions and their interactions with brain-wide activity are involved in action selection is less understood. We have investigated this question by developing an assay based on whole-brain volumetric calcium imaging using light-field microscopy combined with an operant-conditioning task in larval zebrafish. We find global and recurring dynamics of brain states to exhibit pre-motor bifurcations towards mutually exclusive decision outcomes which arises from a spatially distributed network. Within this network the cerebellum shows a particularly strong pre-motor activity, predictive of both the timing and outcome of behavior up to ~10 seconds before…
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