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Our studies on dynamics of biological systems are greatly facilitated by techniques for probing and controlling biological structure and function at different scale at unprecedented speed and resolution. The development of such new tools represents a major focus of our work in which we combine physiology, molecular biology ultrafast and quantum optics. Currently we have developed the following methodologies:

Recording of neuronal activity:
Brain-wide 3D light-field imaging of neuronal activity with speckle-enhanced resolution
High-speed computational imaging, deep in scattering brain tissue using Seeded Iterative Demixing (SID) Microscopy
Fast volumetric calcium imaging across multiple cortical layers using sculpted light
Simultaneous Whole-Brain Functional Imaging of Neuronal Activity using Light-Field Microscopy
High-Speed Brain wide 3D Calcium Imaging of Neuronal Activity with Sculpted Light
Hybrid Light-Sculpting-Scanning for Versatile High-Speed Calcium Imaging
Ultrafast Widefield Optical Sectioning Microscopy<

Manipulating neuronal activity:
Single Neuron Specific Optogenetic Control